A nanomembrane-based nucleic acid sensing platform for portable diagnostics.
نویسندگان
چکیده
In this perspective article, we introduce a potentially transformative DNA/RNA detection technology that promises to replace DNA microarray and real-time PCR for field applications. It represents a new microfluidic technology that fully exploits the small spatial dimensions of a biochip and some new phenomena unique to the micro- and nanoscales. More specifically, it satisfies all the requisites for portable on-field applications: fast, small, sensitive, selective, robust, label- and reagent-free, economical to produce, and possibly PCR-free. We discuss the mechanisms behind the technology and introduce some preliminary designs, test results, and prototypes.
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عنوان ژورنال:
- Topics in current chemistry
دوره 304 شماره
صفحات -
تاریخ انتشار 2011